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KMID : 0361620150500040320
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Journal of the Korean Orthopaedic Association
2015 Volume.50 No. 4 p.320 ~ p.327
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Preliminary Examination for Apoptosis and Cell Proliferation Related to Aging Process in the Anterior Cruciate Ligament Cells of the Human Degenerative Arthritic Knee Joint
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Hyun Rak-Min
Kim Ki-Won
Jeong Seo-Won
Chung Jin-Wha
Lee Hwa-Sung
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Abstract
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Purpose: We investigated the association between aging-induced apoptosis and cell proliferation in the anterior cruciate ligament (ACL) of aged patients.
Materials and Methods: Twenty patients with osteoarthritis who underwent total knee replacement arthroplasty were enrolled in the study. They were divided into three groups according to age: group A (≤65 years), group B (66-75 years), and group C (≥76 years). The ACL tissue was obtained intraoperatively and subjected to terminal deoxynucleotidyl transferase dUTP nick-end labeling staining and immunohistochemistry to quantify the apoptosis and cell proliferation indices.
Results: Apoptosis occurred in all groups, with the highest apoptosis index found in group C, followed by that in groups B and A. A statistically significant positive linear correlation was observed, with a 1-year increase in age resulting in an average increase of 1.49 in the apoptotic index. The lowest cell proliferation index was observed in group C, followed by that in group B and group A, with a 1-year increase in age resulting in an average decrease of 1.0 in the cell proliferation index, which was a statistically significant negative linear correlation. Consequently, a statistically significant negative correlation was confirmed between the apoptosis and cell proliferation indices, whereby an increase of 1.0 in the apoptosis index was concurrent with a decrease of 0.45 in the cell proliferation index.
Conclusion: Apoptosis occurred in the ACL of human knee joint. With increasing age, apoptosis increased and cell proliferation decreased.
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KEYWORD
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knee joint, anterior cruciate ligament, elderly, apoptosis, cell proliferation
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